Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Combination of plaquenil hydroxychloroquine and leflunomide for ra Hydroxychloroquine does this drug treat gout Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. With Plaquenil, the possibility of permanent vision damage scares me. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. I've read elsewhere that Plaquenil is not as strong/effective in the treatment of early RA. With Methotrexate, the reports of nausea and possible liver damage are concerning. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Methotrexate or plaquenil Methotrexate and plaquenil - @Kristinsaba1988., Methotrexate vs Plaquenil Comparison - Can plaquenil lower your calcium numbersDrug store hydroxychloroquineHydroxychloroquine interaction with cyclobenzaprineIs hydroxychloroquine an antibiotic Methotrexate vs plaquenil side effects long term and short term The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. But the Dr suggested I try Methotrexate instead. Methotrexate vs plaquenil side effects long term and short term. Plaquenil vs Methotrexate rheumatoid - reddit. Treatment of Rheumatoid Arthritis with Methotrexate Alone.. Methotrexate - rashes; Does anyone know if hydroxychloroquine and methotrexate can cause weight loss; Does anyone take methotrexate and hydroxychloroquine and has anyone had problems with hydroxychloroquine? Drugs changed from methotrexate to sulphasalazine! Red rash around he eyes due to methotrexate? You just helped educate me. Thanks. I always thought that plaquenil was not a DMARD, but never bothered to look. I do know that plaquenil is generally considered the least invasive drug, generally prescribed as the first line of treatment. Methotrexate is the most commonly prescribed DMARD, but it does come with the chance of side-effects. The effects of methotrexate and hydroxychloroquine combination therapy vs methotrexate monotherapy in early rheumatoid arthritis patients Lisa Schapink. Department of Rheumatology, Sint Maartenskliniek, the Netherlands. Department of Rheumatology, Radboudumc, Nijmegen, the Netherlands.