One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil dosing in renal failure Chloroquine resistant and sensitive areas How Can it Affect Vision? In some cases, Plaquenil can cause visual changes or loss of vision. It is thought that the drug binds to melanin pigmented cells in the retinal pigment epithelium a pigmented layer of cells behind the retina and also damages a layer of cells in the retina called photoreceptors. Find information about common, infrequent and rare side effects of Plaquenil Oral. Summary Blindness is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years, also take medication Humira, and have Pain. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Vision loss from plaquenil New Plaquenil Guidelines -, Common and Rare Side Effects for Plaquenil Oral Plaquenil stomach upsetChloroquine generic brandChloroquine sulphate for rheumatoid arthritisHydroxychloroquine sarcoidosis dosageHydroxychloroquine 200 mg tab ranb Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. Plaquenil Risk Calculators. Will you have Blindness with Plaquenil - eHealthMe. Has anyone experienced plaquenil toxicity with damage to eyes?. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Jun 13, 2019 people taking Plaquenil for 5 or more years; people taking Plaquenil at higher doses than recommended; people who already have retinal disease; people who already have kidney or liver disease; people over 60 years old; people who lose a lot of weight while taking Plaquenil. Tell your doctor if this happens as your dose may need to be lowered. Plaquenil toxicity is typically asymptomatic in early stages, but over time can lead to severe vision loss and retinal damage. The risk of retinal toxicity was initially believed to be less than 1%.