Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Will i lose all of my hair when taking plaquenil Why chloroquine over other medications Hydroxychloroquine 400 mg for rheumatoid arthritis Plaquenil costco Improvement of the hyperpigmentation a few months after hydroxychloroquine is stopped has been reported, but complete clearance is rare. 1 Cautious use of the Q-switched ruby laser has shown promise in the treatment of nonmelanotic hyperpigmentation in limited case reports. 5 Our patient’s skin discoloration partially resolved four months after switching to chloroquine. Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1 Pigmentation appeared after a median duration of hydroxychloroquine treatment of 32 months with a median cumulative dose of 361 g. Overall, two patients reported that the appearance of pigmented lesions was preceded by the occurrence of ecchymotic areas following microtrauma. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine hyperpigmentation treatment Plaquenil Pigmentation - BJC Health, Hydroxychloroquine toxicity - EyeWiki Chloroquine and quinine Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9. Hydroxychloroquine-Associated Hyperpigmentation Mimicking.. Hydroxychloroquine-induced hyperpigmentation in systemic.. Hydroxychloroquine-Induced Hyperpigmentation JCR Journal.. Hydroxychloroquine‐induced hyperpigmentation. 2012-10-01 Dear Editor, Antimalarial agents, including chloroquine and hydroxychloroquine, have been used for the treatment of various rheumatoid diseases and skin disease through their anti‐inflammatory and immune‐modulating properties. Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Using multivariate logistic regression, we found that HCQ-induced pigmentation was independently associated with previous treatment with oral anticoagulants and/or antiplatelet agents and with higher blood HCQ concentration. CONCLUSIONS AND RELEVANCE Hydroxychloroquine-induced pigmentation is not a rare adverse effect of HCQ.