While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta. Chloroquine prep Wallace 1989 chloroquine Chloroquine can be prescribed for either prevention or treatment of malaria. Chloroquine can be prescribed to adults and children of all ages. It can also be safely taken by pregnant women and nursing mothers. Pregnant women are especially susceptible to malaria infection. Without existing immunity, severe malaria can develop requiring emergency treatment, and pregnancy loss is common. In semi-immune women, consequences of malaria for the mother include anaemia while stillbirth, premature delivery and foetal growth restriction affect the developing foetus. Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm. Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area. Pregnant women and chloroquine Drug Safety in Pregnant & Nursing Women, Management of malaria in pregnancy Plaquenil and liver problems Abnormalities 10 - 11. Women on cloroquine therapy should be converted to hydroxychloroquine with adequate time several months before conception to avoid fetal exposure 12. In conclusion the overriding message for clinicians involved in the care of pregnant women with SLE is that close monitoring of maternal disease activity and fetal Treatment of SLE in pregnancy and use of Chloroquine The BMJ. Chloroquine Use During Pregnancy. Medicines for the Prevention of Malaria While Traveling - Chloroquine.. Chloroquine is also used for prophylaxis for pregnant women and non-immune individuals at risk. Dosage and administration. All dosages are described in terms of the base. Treatment. Oral administration. To avoid nausea and vomiting chloroquine should be administered after meals. A baby’s body and most internal organs are formed during the first 12 weeks of pregnancy. It is mainly during this time that some medicines are known to cause birth defects. There is currently no scientific evidence to suggest that women who take chloroquine in pregnancy have a higher chance of having a baby with a birth defect. Pregnancy. There are no adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in pregnant women; usage during pregnancy should be avoided except in prophylaxis or.