Non aqueous titration of chloroquine phosphate

Discussion in 'Aralen' started by sharhan, 14-Mar-2020.

  1. onMonKenko New Member

    Non aqueous titration of chloroquine phosphate


    All the indicators except the three and four-membered-ring cyclic ethers give sharp end-point inflections in titrations of quinuclidine and 8-hydroxyquinoline, but for caffeine only the acetal indicators are satisfactory. Relative standard deviations obtained in replicate determinations of 0.1-mequiv.

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    Dissolve about 0.23 g, accurately weighed, in 20 mL of glacial acetic acid R1 with the aid of heat preferably heat under reflux condenser, cool and add 20 mL of dioxan R. Titrate with perchloric acid 0.1 mol/l VS as described under 2.6 Non-aqueous titration, Method A. How to use Chloroquine Phosphate. Take this medication by mouth, usually with food to prevent stomach upset, exactly as directed by your doctor. Daily or weekly dosing, dosage amount, and length. The assay of chloroquine phosphate and other antimalarials in the drug market to ascertain their quality and suitability for use has, therefore, become a necessity. Analytical methods based on non-aqueous thermometric titration and HPLC have been reported for the assay of chloroquine phosphate 3,4. HPLC-based analytical tools are usually not.

    In the drug titrations, the acetal indicators give the sharpest end-point inflections for chloroquine phosphate. Amounts range from 0.10 to 0.66%, with sample and titrant delivery errors making a significant contribution.

    Non aqueous titration of chloroquine phosphate

    Evaluation of the physicochemical equivalence of three brands., Chloroquine Phosphate - WebMD

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  6. Mg of chloroquine phosphate is approximately equivalent to 150 mg 155 mg of chloroquine base. Requirements Comply with the monograph for Tablets. Definition. Chloroquine phosphate tablets contain Chloroquine phosphate. They contain not less than 93.0% and not more than 107.0% of the amount of chloroquine phosphate C 18 H 26 ClN 3,2H 3 PO 4

    • The International Pharmacopoeia.
    • Bioline International Official Site site up-dated regularly.
    • Nonaqueous titration - Wikipedia.

    Chloroquine phosphate exhibits essentially no optical activity, existing as a racemic mixture. Chloroquine phosphate exists in two polymorphic forms giving rise to two melting ranges. Chloroquine phosphate is freely soluble in water—practically insoluble in alcohol, in chloroform and in ether. The accuracy, as seen in or estimated from the percent recovery studies, was between 96 and 99% with an average of 97.75% in biological materials, common excipients and sampled tablets. Non- aqueous titration was employed as a parallel validation procedure of the described method. Employ the developed method for analysis of chloroquine phosphate in pharmaceutical dosage forms, and to compare between the developed method and the official methods for analysis of chloroquine phosphate formulations. The zero order absorption and first derivative spectra were measured for chloroquine phosphate

     
  7. knopa33 New Member

    Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Hydroxychloroquine - Side Effects, Dosage, Interactions. Plaquenil hydroxychloroquine sulfate dose, indications.
     
  8. Bobr User

    Interferes with digestive vacuole function within sensitive malarial parasites by increasing the p H and interfering with lysosomal degradation of hemoglobin; inhibits locomotion of neutrophils and chemotaxis of eosinophils; impairs complement-dependent antigen-antibody reactions Incomplete and variable (~70% [range: 25 to 100%]) (Tett 1993) Hepatic; metabolites include bidesethylchloroquine, desethylhydroxychloroquine, and desethylchloroquine (Mc Chesney 1966) Urine (15% to 25% [Tett 1993]; as metabolites and unchanged drug [up to 60%, Mc Chesney 1966]); may be enhanced by urinary acidification Rheumatic disease: May require several weeks to respond ~40 days (Tett 1993) ~40%, primarily albumin (Tett 1993) Lupus erythematosus: Treatment of chronic discoid erythematosus and systemic lupus erythematosus in adults. How long for hydroxychloroquine to ta. - Hughes Syndrome Hydroxychloroquine Plaquenil Side Effects & Dosage for. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
  9. turbofox Well-Known Member

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Feb 19, 2020 Plaquenil Hydroxychloroquine may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.

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  10. stur2 User

    Taking Plaquenil for Rheumatoid Arthritis Plaquenil is generally well-tolerated, but side effects are possible. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness.

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