I saw a GP about it (not my usual one) and they strongly suspect it is being caused by MTX but I have just spoken to the Rheumy nurse who thinks Hydroxy is the more likely suspect or it may be an autoimmune response so now I have to withhold all rheumy meds. It seems to improve when I am on steroids but only at higher doses. Thanks, Tamara I am on all sorts of meds including MTX and Hydroxy. Painful muscle spasms from plaquenil Can i take plaquenil and benadryl Does hydroxychloroquine decrease human anti-chimeric antibody Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. A skin rash can be a sign of an allergic reaction to a drug. So you should let your doctor know if your skin breaks out or starts itching. Depending on the type of rash you have and how severe it is, your doctor may lower the dose or stop your medication altogether. I have been on plaquenil for about 3 weeks and I am starting to get a itchy rash. It's pretty mild so far starting on my forearms and now on my chest a little and the rest of my arms. Has anyone else had this problem? Will it go away? I am going to call my doc tomorrow but just wanted someone's. I can't face the GP again, as I am sure I am one of the "heart-sink" patients! I have recently developed an itchy rash which only affects my cheeks and eyebrows and haven't a clue what's causing it, so I hope you get some helpful replies that might help me too! Plaquenil rash and itching Rash from Methotrexate or Hydroxychloroquine? - NRAS, Rheumatoid Arthritis Skin Problems Nodules, Rashes, and More Hydroxychloroquine overdose toxicokinetics and managementPlaquenil cardiotoxicityPlaquenil and essential oilsPlaquenil make toungue Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Rash from plaquenil DailyStrength. Rheumatoid arthritis rash Causes, symptoms, and images. Jun 07, 2019 I am on 400 plaquenil, 10 mg prednisone and was rash from head to toe, ask your rheumatologist for Atarax 10mg 3 times a day, in less than 3 hours I stopped itching and burning, was amazing. fruitlupus Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia and abnormal red blood cells anemia. Plaquenil has been the only drug besides prednisone, but the doctors tell me I can't live on predisone forever that has helped the sclerosis in my stomach which has caused severe gastroparesis caused by the systemic sclerosis. But this itching is getting me to the point where I'm thinking about stopping the medication!