Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine phosphate anemones Chloroquine solution storage Clinical trials are research studies that involve people. The clinical trials on this list are studying Hydroxychloroquine. All trials on the list are supported by NCI. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical. A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme This phase I trial studies the side effects and best dose of hydroxychloroquine in treating patients with solid tumors undergoing radiation therapy for bone metastases. Drugs, such as hydroxychloroquine, may make tumor cells more sensitive to radiation therapy Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Hydroxychloroquine radiotherapy Hydroxychloroquine Oral Uses, Side Effects, Interactions., PDF A PHASE I/II TRIAL OF HYDROXYCHLOROQUINE IN CONJUNCTION. Mechanism of action of chloroquine in malaria Trade Name Plaquenil ® How is this drug used? Plaquenil is used to for the treatment of rheumatoid arthritis RA, some symptoms of lupus, childhood arthritis JIA, and other autoimmune diseases. It is also used for the prevention or treatment of malaria caused by mosquito bites. Plaquenil. Hydroxychloroquine in Treating Patients With Solid Tumors.. Hydroxychloroquine, Radiation, and Temozolomide Treating.. Them from dividing. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving hydroxychloroquine together with temozolomide and radiation therapy may kill more tumor cells. PURPOSE This phase I/II trial is studying the side effects and best dose of hydroxychloroquine when given together with radiation therapy and temozolomide and. Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugsContinue reading Chloroquine & Hydroxychloroquine. This trial is looking at adding hydroxychloroquine to chemotherapy for people with small cell lung cancer that has spread. Lung cancer that has spread is called advanced lung cancer. Recent research shows that a drug called hydroxychloroquine HCQ might help chemotherapy work better. It does this.