One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. How to dissolve chloroquine Chloroquine treatment OverviewPresentationPathophysiologyDiagnosisTreatmentPrognosis This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Clinical observations suggest that hydroxychloroquine is associated with a lower risk of retinopathy than chloroquine, which might be explained by the lower volume of distribution of. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Chloroquine retinopathy mechanism Hydroxychloroquine-Induced Retinal Toxicity - American., Hydroxychloroquine-Induced Retinal Toxicity - American Academy of. What is a potential adverse effect of hydroxychloroquine plaquenilHydroxychloroquine generic priceHydroxychloroquine long term side effects Mechanisms of retinal damage in chloroquine retinopathy. Article in Russian Ivanina TA, Lebedeva MN, Sakina NL, Babizhaev MA, Ermakova VN. The paper presents the results of comparative electron microscopic, electrophysiological and biochemical studies of chloroquine effect on lipid peroxidation LPO both in vitro and in vivo rabbits and. Mechanisms of retinal damage in chloroquine retinopathy.. Mechanisms of action of hydroxychloroquine and chloroquine.. Chloroquine and hydroxychloroquine – Knowledge for medical.. Chloroquine is a potent drug used for the treatment of various diseases, including malaria and a range of connective tissue disorders. Chloroquine retinopathy is an important complication that may appear even years after cessation of the drug, presenting with impaired visual acuity, central vision loss and progressive damage that could result in irreversible blindness. A detailed patient. Chloroquine is a 9-aminoquinoline known since 1934. Apart from its well-known antimalarial effects, the drug has interesting biochemical properties that might be applied against some viral infections. Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses. Its best. The mechanism of action of these drugs remains uncertain but includes effects on the function of lysosomes and components of the immune system. 1,2. It was hoped that the chemical modification of chloroquine to hydroxychloroquine would abrogate its retinal toxicity.