While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. Been on Plaquenil for 30 years for rheumatoid arthritis. I don’t know if I have side effect from this drug as they are intermittent... Chloroquine malaria medication Natural substitute for plaquenil for discoid lupus Hydroxychloroquine can be taken in a single or divided dose to control gastrointestinal side effects. It can also be taken with a glass of milk or meal to minimize nausea. 4,5. When you take this medication, your symptoms may begin to improve in 1 to 2 months. However, it may take up to 6 months to a year before the drug achieves full effect. 3,6 Rated Hydroxychloroquine for Sjogren's Syndrome Report. I started Hydroxychloroquine 2 weeks ago. I was nervous to take it because if side effects. One week in and I thought this may just work. Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Most people who take Plaquenil also take other medicines for pain and stiffness. My eye dr puts me through an hour battery of tests (4? Starting to wonder if I need to increase because my shoulders starting to loose range of motion and had bursitis a few weeks ago in one. Itching - weird times not consistent Eye watering - constant Headaches - hormonal, RA related Always had thin hair - never fell out No stomach issues ever Get eyes checked 1x a year. How long does hydroxychloroquine take to work Hydroxychloroquine Oral Uses, Side Effects, Interactions., Hydroxychloroquine Reviews Everyday Health Plaquenil drug class Hydroxychloroquine along with 30 mg of Prednisone worked for me within 3 months and did a great job. However I had a side reaction- hallucination, so I came off the drug. Plaquenil did not work as well for me,it took about 10 weeks before I saw some effect but again I had a reaction- my fatigue got. How long did Plaquenil/Hydroxychloroquine take? DailyStrength. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil -. How long does it take for plaquenil hydroxychloroquine to work with rashes. How long does it take for plaquenil hydroxychloroquine to work with rashes? 2 doctors weighed in Dr. Bruce Rothschild. Internal Medicine - Rheumatology. 1 doctor agrees In brief 3-6 months, but 3-6 months, but sometimes within a month. Blood work every three months to monitor kidneys. Starting to wonder if I need to increase because my shoulders starting to loose range of motion and had bursitis a few weeks ago in one. Or maybe I need to increase prednisone also 30 years - 5 mg once a dayoff the anti-inflammatory diet though. will get back on it, too. Hydroxychloroquine doesn’t work immediately. It may be 12 weeks or longer before you notice any benefit. Because it's a long-term treatment it's important to keep taking hydroxychloroquine unless you have severe side-effects even if it doesn't seem to be working at first; even when your symptoms improve to help keep the disease under control.