Chloroquine phosphate rheumatoid arthritis

Discussion in 'Canadian Drugs' started by brigadir, 29-Feb-2020.

  1. vga1 User

    Chloroquine phosphate rheumatoid arthritis


    Chloroquine phosphate, which has been used for more than 70 years and is on the World Health Organization’s List of Essential Medicines, the safest and most effective medicines needed in a health system. Chloroquine was discovered in 1934 by Hans Andersag but was initially ignored for a decade because it was considered too toxic for human use.

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    Jul 30, 2019 These side effects were seen most often in patients receiving large doses for treatment of lupus or rheumatoid arthritis; however, such reactions have been noted in patients taking therapeutic doses for short periods. Symptoms often resolved over time with a reduction of the dose or discontinuation of chloroquine. Rheumatoid arthritis. Adults 250 mg P. O. daily chloroquine phosphate with evening meal. Lupus erythematosus. Adults 250 mg P. O. daily chloroquine phosphate with evening meal; reduce dosage gradually over several months when lesions regress. Pharmacodynamics Antimalarial action Chloroquine binds to DNA, interfering with protein synthesis. It also inhibits DNA and RNA polymerases. This report describes the results obtained in a group of 50 consecutive private patients with chronic rheumatoid arthritis who received chloroquine phosphate Aralen as the major medical agent in the management of their disease for 18 to 36 months. The average duration of treatment was 24 months.

    Aside from preventing and treating malaria, chloroquine is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. During World War II, United States government-sponsored clinical trials for antimalarial drug development showed unequivocally that chloroquine has a significant therapeutic value as an antimalarial drug.

    Chloroquine phosphate rheumatoid arthritis

    Chloroquine - Wikipedia, Chloroquine hydrochloride - GLOWM

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  4. Feb 26, 2020 Chloroquine is a very cheap and safe drug that has been used for decades to treat is efficacious as an anti-inflammatory agent for the treatment of rheumatoid arthritis and lupus erythematosus. Consequently, Gao et al,2020 recommends Chloroquine phosphate to treat COVID-19 associated pneumonia in larger populations.

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    Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid arthritis RA, systemic lupus erythematosus SLE and other. Aside from preventing and treating malaria, chloroquine is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. The value of chloroquine in rheumatoid disease a four-year study of continuous therapy. Can Med Assoc J. 1957 Aug 1;77 3182–194. COHEN AS, CALKINS E. A controlled study of chloroquine as an antirheumatic agent. Arthritis Rheum. 1958 Aug;1 4297–312. DUTHIE JJ, THOMPSON M, WEIR MM, FLETCHER WB.

     
  5. mopup Well-Known Member

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses What are the side effects of using hydroxychloroquine. Plaquenil hydroxychloroquine Basics, Side Effects & Reviews.
     
  6. cbeta101 Guest

    Let’s see if we can help you out with the following options: You can perform a search at the top of this page or report a broken link to prevent others from ending up with this error. JUST IN Chloroquine Is The Anti-viral Drug For Coronavirus. Remdesivir A Promising Antiviral Against Coronaviruses Assessment of in vitro prophylactic and therapeutic efficacy.
     
  7. illuminator Guest

    Just Diagnosed with Crest Syndrome & Prescribed Plaquenil. I also am on plaquenil and have been for several years. Diagnosed with systemic scleroderma in 2002. I have developed pulmonary fibrosis in the lower lobe of my left lung last year and have PFT's done every 6months.

    Lupus and Scleroderma - Scleroderma News
     
  8. Pashko Moderator

    Metabolic Encephalopathy - an overview ScienceDirect Topics Metabolic Encephalopathy. Metabolic encephalopathy is the most frequent cause of disordered consciousness in systemic diseases, and is defined as an alteration in consciousness caused by diffuse or global brain dysfunction from impaired cerebral metabolism.

    Plaquenil and Posterior reversible encephalopathy syndrome.