Chloroquine phosphate, which has been used for more than 70 years and is on the World Health Organization’s List of Essential Medicines, the safest and most effective medicines needed in a health system. Chloroquine was discovered in 1934 by Hans Andersag but was initially ignored for a decade because it was considered too toxic for human use. Methotrexate plaquenil prednisone Methotrexate hydroxychloroquine rheumatoid arthritis Ocular toxicity of hydroxychloroquine Natural resources to make chloroquine Jul 30, 2019 These side effects were seen most often in patients receiving large doses for treatment of lupus or rheumatoid arthritis; however, such reactions have been noted in patients taking therapeutic doses for short periods. Symptoms often resolved over time with a reduction of the dose or discontinuation of chloroquine. Rheumatoid arthritis. Adults 250 mg P. O. daily chloroquine phosphate with evening meal. Lupus erythematosus. Adults 250 mg P. O. daily chloroquine phosphate with evening meal; reduce dosage gradually over several months when lesions regress. Pharmacodynamics Antimalarial action Chloroquine binds to DNA, interfering with protein synthesis. It also inhibits DNA and RNA polymerases. This report describes the results obtained in a group of 50 consecutive private patients with chronic rheumatoid arthritis who received chloroquine phosphate Aralen as the major medical agent in the management of their disease for 18 to 36 months. The average duration of treatment was 24 months. Aside from preventing and treating malaria, chloroquine is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. During World War II, United States government-sponsored clinical trials for antimalarial drug development showed unequivocally that chloroquine has a significant therapeutic value as an antimalarial drug. Chloroquine phosphate rheumatoid arthritis Chloroquine - Wikipedia, Chloroquine hydrochloride - GLOWM Can hydroxychloroquine cause hair lossChloroquine phosphate shortage Feb 26, 2020 Chloroquine is a very cheap and safe drug that has been used for decades to treat is efficacious as an anti-inflammatory agent for the treatment of rheumatoid arthritis and lupus erythematosus. Consequently, Gao et al,2020 recommends Chloroquine phosphate to treat COVID-19 associated pneumonia in larger populations. CURE for Coronavirus Found,Chloroquine phosphate has shown.. CHLOROQUINE PHOSPHATE ARALEN IN THE LONG-TERM TREATMENT OF.. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and chloroquine in the treatment of rheumatoid arthritis RA, systemic lupus erythematosus SLE and other. Aside from preventing and treating malaria, chloroquine is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. The value of chloroquine in rheumatoid disease a four-year study of continuous therapy. Can Med Assoc J. 1957 Aug 1;77 3182–194. COHEN AS, CALKINS E. A controlled study of chloroquine as an antirheumatic agent. Arthritis Rheum. 1958 Aug;1 4297–312. DUTHIE JJ, THOMPSON M, WEIR MM, FLETCHER WB.