According to legend it was first brought to Europe by a Countess who had been treated with it in Peru in the 1600s. In 1820, two French chemists isolated quinine from the cinchona bark and quinine became a treatment of reference for intermittent fever throughout the world. Quinine remains an important and effective treatment for malaria today, despite sporadic observations of quinine resistance. Plaquenil rebate Chloroquine phosp hat e Rheumatoid arthritis medication plaquenil CDC has no limits on the use of chloroquine for the prevention of malaria. ANSWER Chloroquine-resistant malaria has been observed in India and so the first line drug of choice should be an artemisinin-derivative in combination with another drug this group of medications are more generally known as "artemisinin-based combination therapies" or ACTs. Traditionally, chloroquine has been the first line drug of choice for uncomplicated, non-resistant malaria. However, several types of malaria, and most notably Plasmodium falciparum, the most severe and deadly kind, has become resistant to chloroquine in many places. These compounds belonged to a new class of antimalarials, the four-amino quinolines. Research by German scientists to discover a substitute for quinine led to the synthesis in 1934 of Resochin (chloroquine) and Sontochin (3-methyl-chloroquine). Chloroquine resistant malaria drug of choice Drug Resistance in the Malaria-Endemic World - CDC, Chloroquine-Resistant Malaria – Lupus medication hydroxychloroquinePlaquenil ankylosing spondylitisPlaquenil therapy and eyes The clinical usefulness of chloroquine, and in some recent cases of quinine as well, has been much reduced by the evolution and spread of chloroquine resistant malaria parasites. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. Chloroquine mechanism of drug action and resistance in.. Drugs for Malaria –. CDC - Malaria - Travelers - Choosing a Drug to Prevent Malaria. Drug-resistant malaria is spreading, but experts clash over its global risk. By Leslie Roberts Oct. 11, 2017, PM. In what scientists call a “sinister development,” a malaria parasite. Drug Resistance In recent years, anti-malarial resistance has been a major concern in treating malaria. For many years, chloroquine CQ was the drug of choice in treating both P. vivax and P. falciparum infections since the drug is cheap and effective. Chloroquine is the drug of choice for treating most patients with malaria caused by P. vivax, P. ovale, P. malariae and chloroquine-sensitive strains of P. falciparum. However, due to the development of resistance, chloroquine is ineffective against most strains of P. falciparum in South America, Africa and Asia.