Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Drugs for ra plaquenil and Hydroxychloroquine burrelia burgdorferi Otis pregnancy hydroxychloroquine Jul 30, 2019 Before the administration of chloroquine, the patient had only a mild skin erythema in the irradiated area, which was consistent with the radiotherapy dose she had received. On day 3 of chloroquine therapy, she developed localized brisk bullous eruptions in the irradiated area, which developed into a patch of fulminant moist desquamation. Chloroquine Sensitizes Nasopharyngeal Carcinoma Cells but Not Nasoepithelial Cells to Irradiation by Blocking Autophagy PLOS ONE, Dec 2019 Anna Makowska, Michael Eble, Kirsten Prescher, Mareike Hoß, Udo Kontny Abstract. Autophagy is an important catabolic process that delivers cytoplasmic material to the lysosome for degradation. Autophagy promotes cell survival by elimination of damaged organelles and proteins aggregates, as well as by facilitating bioenergetic homeostasis. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Atg3 chloroquine and aging EIF5A is required for autophagy by mediating ATG3 translation, Chloroquine Sensitizes Nasopharyngeal Carcinoma Cells but Not. Does plaquenil cause heart palpitations This results from eIF5A‐mediated translation of the E2‐like ATG3 protein, which contains an amino acid motif causing eIF5A dependency for its efficient translation. A high‐throughput screen identifies eIF5A as a translational requirement of autophagy. eIF5A facilitates autophagosome formation by facilitating translation of ATG3. EIF5A is required for autophagy by mediating ATG3 translation.. Regulation and Function of Autophagy during Cell Survival and.. Essential role for the ATG4B protease and autophagy in.. Upon autophagy signal, LC3-I is conjugated by ubiquitin-like proteins Atg7 and Atg3 to the lipid phosphatidylethanolamine PE, generating lipidated LC3-II 14 KDa. The lipidated LC3-II binds to both inner and outer membranes of autophagosomes, with the former being degraded after fusion with lysosomes; whereas LC3 on the outer membrane is deconjugated by ATG4 and returns to the cytosol. Atg12–Atg5 conjugates form larger oligomers with Atg16. Atg8/LC3-I is ligated to the lipid phosphatidyl ethanolamine red wavy lines in reactions assisted by Atg4, Atg7, and Atg3. The role of Atg4 is to cleave the carboxyl terminus of LC3-I to expose a glycine residue. Atg7 and Atg3 assist in the conjugation with the lipid. Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the.