It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Side effects from plaquenil on eye Chloroquine in first trimester pregnancy Chloroquine phosphate for lupus Cost hydroxychloroquine Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Hydroxychloroquine Plaquenil stimulates the pigment producing cells in the skin called melanocytes. As a result, there is both hemosiderin iron and melanin accumulation in the dermis. The exact reasons why this phenomenon happens is not clear. However, in some people hydroxychloroquine can cause skin rashes, especially those made worse by sunlight. feeling sick nausea or indigestion. diarrhoea. headaches. bleaching of the hair or mild hair loss. tinnitus ringing in the ears visual problems. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Hydroxychloroquine skin lightening Plaquenil Side Effects Common, Severe, Long Term -, Skin Pigmentation with Hydroxychloroquine Plaquenil. Taking methotrexate and plaquenil togetherHome remedy for chloroquine itchingHow long do hydroxychloroquine side effects lastPlaquenil alcohol liver Jan 01, 2019 Hydroquinone is a skin bleaching agent which may produce unwanted cosmetic effects if not used as directed. The physician should be familiar with the contents of this insert before prescribing or dispensing this medication. Hydroquinone Cream - FDA prescribing information, side.. Hydroxychloroquine Side-effects, uses, time to work. Hydroxychloroquine-Associated Hyperpigmentation Mimicking.. Use of antimalarials ie, quinacrine, chloroquine, hydroxychloroquine HCQ can induce tissue pigmentation in a variety of organs, including skin, joint tissue, trachea, and cartilage in the nose and ears. Hydroxychloroquine HCQ-associated hyperpigmentation is uncommon, with onset ranging from 3 months to 22 years following the initiation of therapy 1. A 32-year-old woman presented with a 1.5-year history of symmetric polyarthritis, positive rheumatoid factor, and anticyclic citrullinated peptide antibody, without erosive joint changes. Hydroxychloroquine increases lysosomal pH in antigen-presenting cells. In inflammatory conditions, it blocks toll-like receptors on plasmacytoid dendritic cells PDCs. citation needed Hydroxychloroquine, by decreasing TLR signaling, reduces the activation of dendritic cells and the inflammatory process.