It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Buy chloroquine phosphate fish Chloroquine ovarian cancer My question is for those that have taken Plaquenil/Hydroxychloroquine. How long did it take for it to remove symptoms in your personal experience? I know I've read it can take up to 6 months but what I'm wondering is, do you just wake up one day and find it's kicked in 6 months down the road or more likely, it starts to work slowly over 6 months? Re Plaquenil not working anymore Lizzy, I took 400mg 200 twice a day for 16-18 months forget exact duration, then was reduced to 200 mg daily. But right from the start, I also needed NSAID's for pain. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Disease modifers and how to know when plaquenil is working Can plaquenil change blood test results?, Immune & Autoimmune - Lupus Plaquenil not working anymore How does plaquenil affect your eyes Plaquenil never helped me. that was the first medication I was put on. Never felt/saw one bit of difference. Stop plaquenil and started methrotrexate and humira. now just on humira. made a world of difference. off the methrotrexate. now just on humira. still not 100% but so so so much better than first I was 4 months ago. Plaquenil how fast to start working DailyStrength. Taking Plaquenil for Rheumatoid Arthritis. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center. The incidence of new-onset or flaring psoriasis associated with Plaquenil varies from 0-100% depending on which case series report you read! Allergic and psoriasis-like rashes tend to develop within the first few weeks or months of starting Plaquenil. If Plaquenil helps a serious chronic disease such as lupus, it may be taken for years. A We don’t know yet about this virus, says Kevin Winthrop, MD, a specialist in infectious disease epidemiology at OHSU School of Medicine in Portland, Oregon. However, in general, people with autoimmune or inflammatory arthritis who have high disease activity seem to have an increased risk of infections due to greater immune dysregulation. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.