Chloroquine maculopathy cumulative dose

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  1. sitescout New Member

    Chloroquine maculopathy cumulative dose


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Risk for toxicity is least with less than 6.5 mg/kg/day for hydroxychloroquine and 3 mg/kg/day for chloroquine. Patients are at low risk during the first 5 years of treatment. Cumulative use in excess of 250 grams increases the risk for toxic retinopathy. Other risk factors include obesity, kidney or liver disease, older age. Most cases of chloroquine retinopathy have developed when a higher than currently recommended 3 mg/kg/day using lean body weight dose was used. 21 A daily dose exceeding 250 mg with a total cumulative dose between 100 and 300 g is customarily needed to produce toxicity. 22 One study showed a 19% incidence of chloroquine retinopathy in patients taking a mean daily dose of 329 mg. 23 On the other hand, with strict adherence to a low dose per day, the incidence of retinal abnormalities is. The cumulative dose of Chloroquine was previously considered to be of significance as a risk factor for development of maculopathy. This was contradicted by recent studies that suggested that the daily intake adjusted to lean ideal body weight actual body weight—body fat is a more important risk factor 14, 25, 26.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Chloroquine maculopathy cumulative dose

    Recommendations on Screening for Chloroquine and., Chloroquine Retinopathy - an overview ScienceDirect Topics

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  4. A cumulative dose of 1000g of hydroxychloroquine or 460g of chloroquine was likely the largest risk factor, which was typically achieved after 5-7 years of a typical dosage 8, 10. However, there have been case reports of patients with hydroxychloroquine toxicity as early as 1.9 months after starting treatment 11.

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    Cumulative dose 1000 g total HCQ 460 g total CQ Daily Dose Hydroxychloroquine HCQ Chloroquine CQ 400 mg/day 6.5 mg/kg ideal body weight for short individuals 250 mg/day 3.0 mg/kg ideal body weight for short individuals Age Elderly Systemic disease Kidney or liver dysfunction Ocular disease Retinal disease or maculopathy Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. A woman aged 28 years with systemic lupus erythematous and abnormal kidney function, treated with 45 mg/kg hydroxychloroquine daily for 15 years cumulative dose 1369 g, presented with bilateral progressive central vision loss for 2 months. The patient had no known previous exposure to chloroquine. Best corrected visual acuity was 20/40 in her right eye and 20/30 in her left eye. Funduscopy.

     
  5. SpbPro.Ru XenForo Moderator

    Suppression: 400 mg (310 mg base) orally on the same day every week Comments: -Suppressive therapy should begin 2 weeks prior to exposure; however, failing this, an initial dose of 800 mg (620 mg base) may be taken in 2 divided doses (6 hours apart). Chloroquine C18H26ClN3 - PubChem Chloroquine Oral Uses, Side Effects, Interactions, Pictures. Antimalarials in Arthritis by drdoc on-line
     
  6. Eclipse7371502 Moderator

    Granuloma annulare is a common skin condition characterized by bumps appearing over the joints and the backs of the hands. Granuloma Annulare - Pictures, Causes, Treatment and FAQs Moving in to first place Antimalarials for treating. Clinical and Pathological Features of Generalized.
     
  7. Nigting New Member

    Hydroxychloroquine Survey Results - LUPUS UK There are a few different versions of the drug hydroxychloroquine available in the UK. Plaquenil® was the original brand or trade name for hydroxychloroquine and the only other branded product is Quinoric® produced by Bristol Laboratories. Since the patents for these two brands expired and production of Plaquenil was discontinued.

    Hydroxychloroquine - Plaquenil Alternative - LUPUS UK