She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. How does hydroxychloroquine work in ra Hydroxychloroquine quinine She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to presentation. Today, Plaquenil and other antimalarials are also used to treat and help prevent symptoms caused by certain autoimmune diseases such as rheumatoid arthritis RA, systemic lupus erythematosus, and discoid lupus, even though these diseases are not caused by malaria parasites. Plaquenil is the devil! Worked well 1st 2 mts. After that I had issues with my vision, felt waves of nervousness, and extreme anxiety where I started to question my sanity. Hallucinated, broke out in rashes and crying spells. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Symptoms of retinal damage from plaquenil Plaquenil Hydroxychloroquine Sulfate - Sanofi, Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus When to take plaquenilWhen will story on cbs about plaquenil airPlaquenil and quinacrine not working anymore for lupus Symptoms. Over time, Plaquenil can accumulate in the retina and cause permanent irreversible damage to the center of vision. The classic retinal changes appear as a “bull’s eye” area of discoloration of the central part of the retina. Symptoms of Plaquenil toxicity are similar to other macular problems and may include Plaquenil Toxicity Screening - Retina Group of New York. Plaquenil oral Reviews and User Ratings Effectiveness, Ease of Use.. Hydroxychloroquine-Induced Retinal Toxicity - American.. With all of the physical and emotional complications that lupus can cause, it’s easy to overlook symptoms that seem minor at first. But take this advice Don’t ignore changes in vision. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. Prior to any retinal changes or symptoms, the earliest signs of hydroxychloroquine retinopathy are bilateral relative paracentral scotomas 4 to 9 off central fixation and detectable with Amsler grid. These defects can be confirmed by automated perimetry.2,4,10,11 Retinal detachment describes an emergency situation in which a thin layer of tissue the retina at the back of the eye pulls away from its normal position. Retinal detachment separates the retinal cells from the layer of blood vessels that provides oxygen and nourishment.