It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Does chloroquine increase the effects of digoxin Images early plaquenil toxicity fundus autoflurouecense However, dose is usually not more than 800 mg for the first dose and not more than 400 mg for the next doses. For treatment of arthritis Adults—At first, 400 to 600 milligrams mg taken as a single dose or in two divided doses once a day. Hydroxychloroquine is generally prescribed at a daily dose of 6.5 milligrams or less per kilogram of body weight. Using this formula, the dosage for a 150-pound person would be 443 mg/day, as one kilogram equals 2.2 pounds. Because HCQ is formulated as a 200 mg tablet, many people taking it for lupus will take two pills per day. Three anti-malarial drugs are prescribed for lupus symptoms. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Dose of hydroxychloroquine for ther treatment of sle Hydroxychloroquine Professional Patient Advice -, Drug spotlight on hydroxychloroquine Lupus Foundation of. Can you stop taking plaquenilPlaquenil for lyme treatmentChloroquine epilepsy The recommended adult dose for rheumatoid arthritis is 400-600 mg daily for 4-12 weeks followed by 200-400 mg daily. Systemic lupus erythematosus is treated with 400 mg once or twice daily for several weeks then 200-400 mg daily. Hydroxychloroquine should be taken with food or milk in order to reduce stomach upset. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Clinical Impact of Decreasing Hydroxychloroquine Dose.. INTRODUCTION Hydroxychloroquine HCQ is an alkalinizing lysosomatropic drug that accumulates in lysosomes where it inhibits some important functions by increasing the pH. HCQ has proved to be effective in a number of autoimmune diseases including systemic lupus erythematosus SLE. At the 2018 ACR/ARHP Annual Meeting, I had the opportunity to co-moderate this year's Great Debate, which was titled "Guidelines for SLE HCQ Dose Should Be No More Than 5 mg/kg In All Patients." Dr. Nathalie Costedoat-Chalumeau of the Cochin Hospital in Paris began the symposium by briefly discussing the risks and benefits of hydroxychloroquine HCQ, and her own work on the use of hydroxychloroquine blood levels. In rare cases, hydroxychloroquine can cause visual changes or loss of vision. Such vision problems are more likely to occur in individuals taking high doses for many years, individuals 60 years or older, or those with significant kidney disease. At the recommended dose, development of visual problems due to the medication is rare.