About 5-30% of autoimmune patients are inclined to develop additional autoimmune diseases leading to the development of overlap diseases. An overlap between Lupus and Rheumatoid Arthritis (RA) referred to as Rhupus has been much on debate, whether it represents a single distinct entity or an overlap disease? du Montcel ST, Michou L, Petit-Teixeira E, Osorio J, Lemaire I, Lasbleiz S et al. Korendowych E, Owen P, Ravindran J, Carmichael C, Mc Hugh N. Orozco G, Eyre S, Hinks A, Bowes J, Morgan AW, Wilson AG et al. Hydroxychloroquine and citrus Chloroquine cocktail with valium and zopiclone Tongue swelling from plaquenil Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic, it can take up to six months' constant use before an effect is seen in RA 1. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil was actually first classified as an antimalarial drug, but it is also used to treat certain rheumatic and autoimmune conditions which are unrelated to malaria. Generally, Plaquenil is a treatment option as monotherapy used alone for mild rheumatoid arthritis or as combination therapy with other DMARDs for moderate to severe disease. Discussion Rhupus is known to be a complex musculoskeletal autoimmune disease defined by erosive polyarthritis. Herein we reviewed the literature over the past 54 years to characterise rhupus subjects and to support the theory of overlap. HLA class II association with rheumatoid arthritis: facts and interpretations. New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility. The clinical and genetic associations of anti-cyclic citrullinated peptide antibodies in psoriatic arthritis. Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus. Does plaquenil treat rhupus Plaquenil -, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil and atenololPlaquenil tablets side effects Plaquenil Hydroxychloroquine. The drug of choice for systemic lupus erythematosus SLE or "Lupus" and rheumatoid arthritis. Hydroxychloroquine is a one of a number of drugs which have been used for many years in the treatment of malaria. Fortunately, it was discovered these drugs often are helpful in the treatment of various rheumatic diseases. Plaquenil. A medication for Lupus. Taking Plaquenil for Rheumatoid Arthritis. Rhupus A crosswalk between lupus and rheumatoid arthritis.. According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with arthritis. It can also reduce the incidence of joint damage. Initial dose for the treatment of SLE, 400mg×2/day, is about the dose used in one of the studies above. Maintenance dose would keep the serum concentration constant. Assuming HCQ is effective, it would most definitely be protective in doses used in SLE patients. Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation.