Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Chloroquine nightmares Hydroxychloroquine dosing lyme Hydroxychloroquine hcq Chloroquine cyclosporin For lupus erythematosus, one or two tablets are usually taken once or twice daily. For rheumatoid arthritis, one to three tablets are usually taken once a day. Hydroxychloroquine can be taken with a glass of milk or a meal to decrease nausea. Follow the directions on your prescription label carefully. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling especially of the face/tongue/throat, dizziness, trouble breathing. This is not a complete list of possible side effects. The rash can be mild or severe but is not usually painful. It can be itchy if it is more like a rash than a blush and some patients even report a ‘hot’ feeling with more severe malar rashes. This type of rash tends to occur in the systemic form of the disease SLE, where other organs in the body may also be involved. 2. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can hydroxychloroquine cause a lupus type rash Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, Plaquenil Oral Uses, Side Effects, Interactions. Can you drink alcohol on hydroxychloroquinePlaquenil drug studyHydroxychloroquine vs malarone Hydroxychloroquine, originally used as an antimalarial agent, has beneficial effects on mucocutaneous symptoms in systemic lupus erythematosus. It is also used for the skin rash of discoid lupus erythematosus. A number of rare but serious adverse reactions can occur with its use and are usually associated with long-term therapy. Risks of Hydroxychloroquine. Coping with Itchy Rashes - LUPUS UK. Plaquenil Side Effects Common, Severe, Long Term -. I had been taking plaquenil since April for my lupus and sjogrens. It was working really well and just recently my rheumy told that I was in remission. I felt great. Then I had an allergic reaction to the plaquenil - a rash all over my body, neck, arms and legs. I stopped taking it 1 week ago. I believe that the difference between generic and brand name Plaquenil is possibly sulfa. I can take brand name Plaquenil the first few weeks cause stomach upset, but if I take the generic - I get a rash, sore throat and it's hard to swallow. Exactly what I get when I took a sulfa drug when I was a child. The generic probably contains sulfa. An increased incidence of cutaneous reactions to hydroxychloroquine has been postulated to occur in patients with dermatomyositis. OBJECTIVE To determine if adverse cutaneous eruptions due to hydroxychloroquine are more common in patients with dermatomyositis than in those with cutaneous lupus erythematosus.