Plaquenil retinopathy visual fields

Discussion in 'Generic Chloroquine' started by 123av, 11-Mar-2020.

  1. Nikitos777 Well-Known Member

    Plaquenil retinopathy visual fields


    Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology.

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    Hydroxychloroquine retinopathy is thought to be infrequent but of increasing prevalence because patients use the drug for many years or have undue exposure from overdosage or renal failure. 1 Screening in previous decades was primarily by subjective functional measures, such as the central visual field. A cookie-cutter approach to dosing Plaquenil hydroxychloroquine, Sanofi-Aventis, an anti-malarial drug that has been used as a treatment for systemic lupus erythematosus and rheumatoid arthritis. Paracentral scotomas have been reported prior to the associated maculopathy, so an amsler grid test or central 10-2 visual field perimetry was recommended. 2,5 Additionally, color vision––helping in the assessment of macular integrity––was recommended as an optional test.

    While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula.

    Plaquenil retinopathy visual fields

    Bull's-eye maculopathy due to hydroxychloroquine toxicity, Despite Plaquenil dosing recommendations, retinal toxicity.

  2. Hydroxychloroquine
  3. Plaquenil therapy and eye exams. De__0__0. I was told from the start by my rheumatologist I would have to have eye exams including visual field exams every six months due to the plaquenil therapy. My first two exams did include these tests. But my next six month appointment is coming up, and they told me I didn't need the visual field test.

    • Plaquenil therapy and eye exams. - Eye Care - MedHelp.
    • New Plaquenil Guidelines.
    • Plaquenil - FDA prescribing information, side effects and uses.

    The earliest signs of HCQ retinopathy on a central visual field may present as a cluster of paracentral points with decreased sensitivity. These points may be only mildly depressed. Further, HCQ retinopathy leads to a partial bull's eye scotoma that may resemble an arcuate defect although it is more central than that commonly seen from glaucomatous damage Fig. 1. Nov 01, 2015 Advanced cases may demonstrate widespread retinal pigment epithelium atrophy, with a reduced visual field and decreased night vision. 3. Visual field. Parafoveal sensitivity loss is an early sign that may precede fundus changes. A computerized white-on-white 10-2 visual field test enables good resolution to test for macular sensitivity. Screening requires the use of tests, such as 10–2 visual fields and SD-OCT and other modern techniques, such as autofluorescence imaging and multifocal electroretinography, to demonstrate early retinal damage.” 1 Melles & Marmor. The Risk of Toxic Retinopathy in Patients on Long-term Hydroxychloroquine Therapy.

     
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  5. sa2nt User

    the cause of the most lethal human malaria, chloroquine resistance is linked to multiple mutations in Pf CRT, a protein that likely functions as a transporter in the parasite’s digestive vacuole membrane. Chloroquine-Resistant Malaria The Journal of Infectious. CHLOROQUINE-RESISTANT PLASMODIUM FALCIPARUM MALARIA IN THE. Chloroquine Resistance in Plasmodium falciparum - microbewiki
     
  6. Ebola User

    Healthboards - Immune & Autoimmune - Lupus Lupus and ear probs? Some really bazaar rashes that do not itch have been popping up. They look almost like blisters that are not puffy, and go away without anything in a few days. Some scarring, but nothing significant. Anyways my main quiestion involved Lupus and ear probs.

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