I saw a GP about it (not my usual one) and they strongly suspect it is being caused by MTX but I have just spoken to the Rheumy nurse who thinks Hydroxy is the more likely suspect or it may be an autoimmune response so now I have to withhold all rheumy meds. It seems to improve when I am on steroids but only at higher doses. Thanks, Tamara I am on all sorts of meds including MTX and Hydroxy. Plaquenil pregnan Metformin versus hydroxychloroquine for tyle 2 diabetes Hydroxychloroquine dizziness Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine Hydroxychloroquine can cause irreversible retinal toxicity, resulting in bilateral bull’s eye retinopathy, but is regarded as less toxic to the retina than chloroquine and it does not cause the corneal deposits seen with chloroquine therapy. Rashes may occur in up to 10% of patients. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. I can't face the GP again, as I am sure I am one of the "heart-sink" patients! I have recently developed an itchy rash which only affects my cheeks and eyebrows and haven't a clue what's causing it, so I hope you get some helpful replies that might help me too! Hydroxychloroquine causing rash where Plaqunil rash -, Hydroxychloroquine DermNet NZ Hydroxychloroquine 200mg coupon rxgo Background Hydroxychloroquine sulfate and other antimalarial drugs have been used successfully as adjunctive therapy for patients with cutaneous lesions of dermatomyositis over the past 20 years. An increased incidence of cutaneous reactions to hydroxychloroquine has been postulated to occur in patients with dermatomyositis. Adverse Cutaneous Reactions to Hydroxychloroquine Are More.. Hydroxychloroquine - Wikipedia. Hydroxychloroquine Skin Support. Plaquenil and Rashes - from FDA reports Summary Rashes is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 1 month, also take medication Enbrel, and have Pain. I had an itchy rash due to methotrexate. They thought it was most likely to be caused by Cimzia, so stopped both drugs, restarted MTX and the rash came back. So I had to stop that and started on new medication after the rash had subsided. The doctor hasn't seen that before, so it's not always the cause. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects.