Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Chloroquine mechanism of action in rheumatoid arthritis Does hydroxychloroquine cause diarrhea Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis or juvenile idiopathic arthritis and other autoimmune diseases. It is not clear why hydroxychloroquine is effective at treating autoimmune diseases. Immunosuppressive drugs, including cyclophosphamide and azathioprine, and adrenal hormones, such as prednisone PDS, are clinical drugs used in the treatment of LN 2,3. However, these drugs present significant side effects with long-term and high-dose application. A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. A 4-aminoquinoline with antimalarial and immunosuppressive properties. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. How immunosuppressant is hydroxychloroquine Immunosuppressive therapy and sarcoidosis - Cleveland Clinic, Immunosuppressive effects of hydroxychloroquine and. Hydroxychloroquine sulfate 200 mg oral tablet verifiedIs plaquenil the same as hydroxychloroquineIcd 10 plaquenil screening Hydroxychloroquine HCQ, a lysosomotropic amine, is an immunosuppressive agent presently being evaluated in bone marrow transplant patients to treat graft-versus-host disease. While its immunosuppressive properties have been attributed primarily to its ability to interfere with antigen processing, recent reports demonstrate HCQ also blocks T-cell activation in vitro. Hydroxychloroquine inhibits calcium signals in T cells a new.. Hydroxychloroquine. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. For individuals with significant risk factors daily dose of hydroxychloroquine sulfate 5.0 mg/kg base of actual body weight, subnormal glomerular filtration, use of tamoxifen citrate or concurrent macular disease monitoring should include annual examinations which include BCVA, VF and SD-OCT; for individuals without significant risk. Hydroxychloroquine Plaquenil Is an Immunosuppressant. In my opinion, Plaquenil is best considered an immunosuppressant. It’s true that it’s different than other immunosuppressants like methotrexate or cyclosporine. It does not seem to predispose to cancer development but does predispose to some infections. Immunosuppressant / Disease Modifying Medications In addition to medications that are used to treat individual symptoms thes are covered below, a number of different medications used in treating systemic scleroderma patients are designed to interrupt the disease process in a variety of ways.