Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine long half life Antimalarial drugs chloroquine and primaquine Children should not take hydroxychloroquine for long-term therapy. Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to hydroxychloroquine. If you are taking hydroxychloroquine for a long period of time, your doctor will recommend frequent eye exams. Changes to the menstrual cycle don't appear to be listed as a known side-effect of hydroxychloroquine, but that doesn't necessarily mean that it couldn't be involved. It may be worth discussing with your doctor. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine and menstrual cycle Hydroxychloroquine Side-effects, uses, time to work, MENSTRUAL ISSUES - HYDROXYCHLOROQUINE A BIG HELLO. How long for chloroquine to work Saturday was a week since I stopped taking Plaquenil, aka Hydroxychloroquine, per my doctor's instructions, and I think I am going through some form of withdrawal. I took the drug as a treatment for sarcoidosis and one of the side effects is a reduction in white blood cells, which is what has happened to me. Plaquenil Withdrawal – Life As An Anomaly. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Hydroxychloroquine - Drugs and Lactation Database LactMed.. However, hydroxychloroquine has an extremely favorable toxicity profile and is widely considered to be safe to use in the perioperative period as it is not a potent immunosuppressant. Leflunomide, sulfasalazine, and azathiaprine all have immunosuppressive properties and can be toxic at high levels. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine treats malaria, systemic lupus erythematosus, rheumatic disorders like rheumatoid arthritis, porphyria cutanea tarda, and Q fever. 1 In 2014, its efficacy to treat Sjögren syndrome was questioned in a double-blind study involving 120 patients over a 48-week period.