Chloroquine heme polymerase

Discussion in 'Hydroxychloroquine Plaquenil' started by Eventually, 28-Feb-2020.

  1. Chaser23 New Member

    Chloroquine heme polymerase


    These hematophagous organisms such as Malaria parasites (Plasmodium spp.), Rhodnius and Schistosoma digest haemoglobin and release high quantities of free heme, which is the non-protein component of hemoglobin. Heme is a prosthetic group consisting of an iron atom contained in the center of a heterocyclic porphyrin ring.

    Plaquenil for lupus review inflammation Trade name chloroquine

    It has high affinity for chloroquine, which is another mechanism for trapping chloroquine. Once trapped, chloroquine acts by one of many ways a. Inactivation of heme-polymerase responsible for conversion of heme part of hemoglobin into hemozoin. Conversion does not take place, heme is toxic to plasmodium, resulting in death of plasmodium. b. Chloroquine is a chemotherapeutic agent for the clinical treatment of malaria. Chloroquine is able to bind to DNA, and inhibit DNA replication and RNA synthesis which in turn results in cell death. The effect of Chloroquine may also be related to the formation of a toxic heme-Chloroquine complex. New data are also presented which show that heme polymerase isolated from chloroquine resistant trophozoites retains full sensitivity to drug inhibition, consistent with the observation that resistance involves a reduced accumulation of the drug at the still vulnerable target site.

    In malaria parasites, hemozoin is often called malaria pigment. Free heme is toxic to cells, so the parasites convert it into an insoluble crystalline form called hemozoin.

    Chloroquine heme polymerase

    What is the role of hemozoin in the etiology of malaria?, Chloroquine diphosphate ≥99%HPLC Selleck ATM/ATR.

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  3. Aug 23, 2017 Chloroquine is a medication prevent or to treat malaria, a disease caused by parasites. This medicine works by interfering with the growth of parasites from the human body’s red blood cells. Parasites that cause malaria enter the body via the bite of a mosquito.

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    Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. THE incidence of human malaria has increased during the past 20 years; 270 million people are now estimated to be infected with the parasite1. An important contribution to this increase has been. This heme is used up by parasitic polymerase enzyme and converted to non toxic haemozoin. Since Chloroquine is a weak base it has high affinity towards acidic lysosome. Chloroquine inhibits polymerase enzyme and interfere the formation of haemozoin and results in accumulation of toxic haeme and also it binds with haeme to form haeme- Chloroquine.

     
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