Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Hydroxychloroquine retinopathy mechanism Chloroquine pronounce Fundus autofluorescence in hydroxychloroquine toxicity Apr 20, 2011 The goal of monitoring/screening is to identify early macular damage prior to irreversible vision loss or even before visible signs of bull’s eye maculopathy. And although the current guidelines do not discuss the importance of continuous ocular care with an annual comprehensive eye exam, we believe that it is an essential consideration. 1. All individuals starting Plaquenil treatment should have a baseline ophthalmologic examination within the first year. If the initial ophthalmologic examination is normal and the person is considered low risk, re-testing need not occur for five years. SIDE is rare. It is recommended that you have an eye exam EFFECTS HOW TO TAKE IT Hydroxychloroquine comes in an oral tablet. Adult dosing ranges from 200mg or 400mg per day 5 mg per kg of actual body weight. In some cases, higher doses can be used. It is recommended one tablet twice daily if taking more than one tablet. It is also recommended to be Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Do you need a baseline eye exam before taking hydroxychloroquine Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, Taking Plaquenil for Rheumatoid Arthritis Hydroxychloroquine and dextromethorphan togetherSkin splits on fingertips hydroxychloroquineNon aqueous titration of chloroquineVertigo from plaquenil May 02, 2007 They have to examine you to see if you have anything of concern that they can determine that is NOT caused by Plaquenil which is why the baseline exam is important. If your exam showed something after taking the Plaq, then they would not be able to determine if it was caused by Plaq or was pre-existent. Eye exam / Plaquenil -. PATIENT FACT SHEET Hydroxychloroquine Plaquenil. Plaquenil Side Effects on Your Eyes and Vision. May 24, 2017 As I mentioned before, hydroxychloroquine eye toxicity is not reversible. Once it happens, it happens. So the trick is to catch it early. Fortunately, the changes occur VERY slowly. The American Academy of Ophthalmology recommends the following Obtain a baseline eye exam within the first year of starting hydroxychloroquine to document any complicating eye problem. Jun 13, 2019 Before Plaquenil treatment begins. You will have a “baseline” eye exam. This measures the health of your eyes and looks for retinal or macular disease. Once a year while taking Plaquenil. After five years of Plaquenil treatment, when retina damage is likely to begin, you need to see your ophthalmologist every six months. Special tests can help find early damage to the retina before serious problems develop. Nov 09, 2018 While using hydroxychloroquine, you may need frequent blood tests and vision exams. Store at room temperature away from moisture, heat, and light. Seek emergency medical attention or call the.