Chloroquine prophylaxis in pregnancy

Discussion in 'Northwest Pharmacy Canada' started by Ellea, 01-Mar-2020.

  1. Kosyan Guest

    Chloroquine prophylaxis in pregnancy


    They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Malaria article more useful, or one of our other health articles.

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    When comparing chloroquine and sulfadoxine-pyrimethamine as intermittent therapy for the treatment of malaria in pregnant women — in a setting of high resistance to sulfadoxine-pyrimethamine. To determine the effect of chloroquine chemoprophylaxis during pregnancy on birth weights, a randomized trial was carried out in 19 in Banfora, Burkina Faso West Africa. Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments-If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate 600 mg base may be taken orally in 2 divided doses, 6 hours apart.

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it.

    Chloroquine prophylaxis in pregnancy

    CHLOROQUINE PHOSPHATE, USP, Effect of Chloroquine Chemoprophylaxis during Pregnancy on.

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  4. Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm.

    • Chloroquine Use During Pregnancy.
    • Chloroquine Dosage Guide with Precautions -.
    • Chloroquine for Malaria in Pregnancy - Full Text View..

    Jun 29, 2012 Blood Stage Prophylaxis In Vivax Malaria. Blood stage prophylaxis is the most common type of prophylaxis in use. Chloroquine, was the first drug in this group to be extensively used. It was introduced in the early 1950’s for the prevention of both falciparum and vivax malaria. Although there is a need for more effective malaria chemoprevention strategies in. pregnancy in east and southern Africa, evidence from the trial by Divala and colleagues is. unlikely to swing the pendulum back in favour of chloroquine prophylaxis. Use in pregnancy. There is no evidence that chloroquine is harmful in prophylactic doses during pregnancy. Because of the susceptibility of pregnant women to falciparum malaria, it should be used at the recommended dosage for both prophylaxis and treatment wherever chloroquine-sensitive malaria is prevalent. Adverse effects

     
  5. k4kreesh Well-Known Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine and desethylchloroquine concentrations in blood cells and. High sensitivity methods to quantify chloroquine and its metabolite in. Dose Optimization of Chloroquine by Pharmacokinetic.
     
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  7. domains365 Moderator

    Chloroquine and Hydroxychloroquine Toxicity Treatment. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ.

    Chloroquine And Hydroxychloroquine Toxicity - StatPearls.