Please review the following URL and make sure that it is spelled correctly. Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Skin splits on fingertips hydroxychloroquine Chloroquine side effects depression Plaquenil and nerve damage Chloroquine solubility in water Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic, it can take up to six months' constant use before an effect is seen in RA 1. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Plaquenil and nodules Nodules in the muscles and tendons?, Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Chloroquine or proguanilPlaquenil tablets I've had the nodules removed several times and each time they are positive rheumatoid nodules. I was on plaquenil and methotrexate, however, I came off methotrexate in 2009 due to pregnancy. Rheumatoid Arthritis Nodules - News Medical. Plaquenil Side Effects Common, Severe, Long Term -. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. I had some issues with the plaquenil, nausea and extremity swelling. My rheumy told me that he has never had anyone have leg and hand swelling on plaquenil but he does not doubt it is from the plaquenil. I'm off the prednisone and must say that I am working on adapting to the plaquenil because I can tell it is helping. Lung nodule is found among people who take Plaquenil, especially for people who are female, 40-49 old also take medication Remicade. This study is created by eHealthMe based on reports of 48,911 people who have side effects when taking Plaquenil from Food and Drug Administration FDA, and is updated regularly. A CT scan can find very small nodules, as small as 1-2 mm in diameter. If the nodule is small enough or if its features suggest a very low likelihood that it represents a cancer, your doctor is likely to follow the nodule over time with repeated chest imaging. If the nodule does not grow over time, it is confirmed to be benign.