Chloroquine phosphate solubility storage

Discussion in 'Northwest Pharmacy' started by Katee11, 12-Mar-2020.

  1. mynameisAlex Moderator

    Chloroquine phosphate solubility storage


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine is a member of quinolone family and is a weak intercalating agent. Chloroquine is used for treating amebiasis, rheumatoid arthritis, discoid and systemic lupus erythematosus. Application DNA intercalator. Also used to increase transfection efficiency. Chloroquine diphosphate salt has been used • in in vitro antiplasmodial assays Page 3 of 6 Chloroquine phosphate SAFETY DATA SHEET 6.3 6.1 6.2 Section 6. Accidental Release Measures Contain spill and collect, as appropriate. Transfer to a chemical waste container for disposal in accordance with local regulations. Methods and Material For Containment and Cleaning Up Avoid raising and breathing dust, and provide. Solubility. Soluble in 4 parts of water; very slightly soluble in ethanol ~750 g/l TS and ether R. Category. Antimalarial; antiamoebic. Storage. Chloroquine phosphate should be kept in a well-closed container, protected from light. Additional information. Chloroquine phosphate has a bitter taste; it is slowly discoloured by light.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine phosphate solubility storage

    Chloroquine - Wikipedia, SAFETY DATA SHEET Page 1 of 6 Chloroquine phosphate.

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  7. On the basis of the solubility data, it can be observed that the highest solubilities for chloroquine diphosphate and 4,7-dichloroquinoline were obtained in pure water and tetrahydrofuran, respectively. The temperature dependence of the solubility data was correlated by the modified Apelblat model.

    • Solubility of Chloroquine Diphosphate and 4,7..
    • Monographs Pharmaceutical substances Chloroquine phosphate..
    • CHLOROQUINE PHOSPHATE, USP - Sanofi.

    Each tablet contains 500 mg of Chloroquine phosphate USP, equivalent to 300 mg Chloroquine base. Inactive Ingredients colloidal silicon dioxide, dibasic calcium phosphate, hydroxypropylmethylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate80, pregelatinized starch, sodium starch glycolate and titanium dioxide. Mean bioavailability from tablets of chloroquine phosphate is 89%. Chloroquine is widely distributed in body tissues such as the eyes, kidneys, liver, and lungs where retention is prolonged. The elimination of chloroquine is slow, with a multi exponential decline in plasma concentration. The dose written on the labels is sometimes in chloroquine salt and sometimes in chloroquine base which leads to frequent confusion. The WHO recommends prescriptions and labels in chloroquine base. 100 mg base = approx. 130 mg sulfate = approx. 160 mg phosphate or diphosphate 155 mg base = approx. 200 mg sulfate = approx.

     
  8. LeoMatty Guest

    , also known as apparent volume of distribution) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma.) is possible, and would indicate that the drug is highly distributed into tissue. Chloroquine & Hydroxychloroquine supporting chemo. The pharmacokinetics of three multiple dose regimens of. Disposition of chloroquine in man after single intravenous and oral doses.
     
  9. WebKiller Guest

    Anti-LC3-I/II Antibody Sigma-Aldrich LC3-II is the first mammalian protein identified that specifically associates with autophagosome membranes. Specificity This antibody detects both the non-lipidated LC3-I non-autophagic and lipidated LC3-II autophagic under autophagy conditions.

    FAQs - Autophagy and LC3 - Novus Biologicals
     
  10. neptune XenForo Moderator

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects. Hydroxychloroquine sulfate is a colorless crystalline solid, soluble in water to at least 20 percent; chemically the drug is 2-4-7-Chloro-4-quinolylaminopentylethylamino ethanol sulfate 11. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration.

    Hydroxychloroquine‐induced hyperpigmentation the staining.