Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This medication is used to kill the malaria parasites living inside red blood cells. Plaquenil methotrexate Plaquenil and heart disease Does plaquenil work without methotrexate Some side effects of chloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Compare Chloroquine vs Hydroxychloroquine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Chloroquine rated 10.0/10 vs Hydroxychloroquine rated 6.7/10 in overall patient satisfaction. Answer 1 of 17 Did anybody have any serious side effects after using these anti-malarian drugs? I was told by the doctor that Malarone is much better but also much more expensive. Both drugs may be needed for a complete cure and to prevent the return of infection (relapse). In some cases, you may need to take a different medication (such as primaquine) to kill the malaria parasites living in other body tissues. Chloroquine and proguanil side effects Side Effects of Malarone Atovaquone and Proguanil Hcl., Chloroquine vs Hydroxychloroquine Comparison - Hydroxychloroquine generic nameEye 5est to check eyes when taking plaquenilChloroquine phosphate anemones A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including rash, itching/swelling especially of the face/tongue/throat, severe dizziness, trouble breathing. This is not a complete list of possible side effects. Chloroquine Oral Uses, Side Effects, Interactions.. Chloroquine and Proguanil - side effects - Goa Forum.. Side Effects of Malarone Atovaquone and Proguanil Hcl, Warnings, Uses. Atovaquone and proguanil are medications to treat malaria, a disease caused by parasites. These medicines work by interfering with the growth of parasites in the red blood cells of the human body. For the Consumer. Cold, clammy skin. decreased urine. drowsiness. dry mouth. fast, weak pulse. increased thirst. lightheadedness, dizziness, or fainting. loss of appetite. muscle pain or cramps. numbness or tingling in the hands, feet, or lips. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about.