Chloroquine retinopathy after drug cessation

Discussion in 'Pharmacy Northwest Canada' started by vitalik.mariupol, 18-Mar-2020.

  1. Stassius Well-Known Member

    Chloroquine retinopathy after drug cessation


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Clearance of the HCQ from blood and urine can take months to years after drug cessation and visual function may continue to deteriorate slowly even after the therapy was stopped. Hydroxychloroquine Retinopathy. Chloroquine retinopathy was described for the first time in the early ’60s. Chloroquine CQ has been used widely for the treatment of rheumatoid arthritis RA and significant central visual loss associated with this drug has been reported 1. Prevalence of CQ maculopathy was 13.5% among RA patients taking CQ. Importance Given the infrequent occurrence of hydroxychloroquine toxic effects, few data are available about the presenting features and long-term follow-up of patients with hydroxychloroquine retinopathy, making it difficult to surmise the clinical course of patients after cessation of drug treatment.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Chloroquine retinopathy after drug cessation

    Long-Term Course of Chloroquine Retinopathy after Cessation., Long-term continuation of chloroquine-induced retinal.

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  5. Chloroquine retinopathy is an important complication that may appear even years after cessation of the drug, presenting with impaired visual acuity, central vision loss and progressive damage that could result in irreversible blindness. A detailed patient history that confirms chloroquine use is essential, while advanced ophthalmologic methods must be employed to assess the status of the retina.

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    Oct 01, 2018 Radioactively tagged Chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across the placenta and accumulated selectively in the melanin structures of the fetal eyes. It was retained in the ocular tissues for five months after the drug had been eliminated from the rest of the body 2. There are no adequate and well-controlled studies evaluating the safety and efficacy of Chloroquine in pregnant women. Conclusions CQ retinopathy can progress over a long period of time after drug cessation and may be complicated by cystoid macular oedema, epiretinal membrane formation and peripheral involvement. Aims To evaluate progression of morphological alterations in chloroquine CQ or hydroxychloroquine HCQ retinopathy after drug cessation. Chloroquine is stored in tissues such as the liver and especially the pigmented uveal ocular tissue. 10 Urinary excretion of chloroquine continues years after cessation of chloroquine. 10 These findings buttress the diagnosis of late onset chloroquine retinopathy in our patient.

     
  6. aaasdcczz Moderator

    Download PDF Many systemic medications may cause retinal toxicity. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Hydroxychloroquine Plaquenil Toxicity and. How Do Ophthalmologists Look for Plaquenil Damage.
     
  7. Seo-Sdart XenForo Moderator

    Hydroxychloroquine Side Effects, Dosage, Uses, and More Serious side effects and their symptoms can include the following blurred vision or other vision changes. ringing in your ears or hearing loss. angioedema, or rapid swelling of your skin. hives. mild or severe bronchospasm that causes trouble breathing. sore throat. unusual bleeding or.

    The Risk of Retinal Toxicity with Plaquenil