I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Can plaquenil inflame crohns disease Plaquenil for ovarian cancer Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. The prednisone is a steriod and the plaquenil is a anti malaria drug. The thing with plaquenil for me is that I don't notice much of anything taking it but when I go off then I flare up and then really notice it. I have been taking the plaquinil for about 8 years morning and night and the prednisone off and on. Take Plaquenil for the full prescribed length of time for malaria. Your symptoms may improve before the infection is completely cleared. When treating lupus or arthritis, tell your doctor if your symptoms do not improve after 6 months of treatment. Before taking this medicine. You should not use Plaquenil if you are allergic to hydroxychloroquine. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. Should you take plaquenil with steroids Prednisone and Plaquenil question" Lupus Community., Prednisone and Plaquenil DailyStrength Folic acid and hydroxychloroquine dosing sleIs plaquenil addictiveOct hydroxychloroquine retinopathyPlaquenil and macular degeneration Dec 15, 2010 hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. Methotrexate and plaquenil -. Plaquenil Uses, Dosage & Side Effects -. Danger in taking Plaquenil and Prednisone if its not Lupus.. Do not abruptly stop taking steroids. You should not stop taking steroids abruptly if you have been taking them for more than 4 weeks. Once your body has adjusted to taking steroids, your adrenal glands may shrink and produce less natural cortisone. There are guidelines on the amount of Plaquenil a person should be able to take safely in a lifetime, and Katz encourages those taking the medication to discuss this with their ophthalmologists. “I think there are some people, like Ann, whose bodies, for whatever reason, don’t metabolize drugs as well,” he says. Compare Plaquenil vs. Prednisone, which is better for uses like Lupus, RA and Sjogren's Syndrome. Compare head-to-head ratings, side effects, warnings, dosages, interactions and patient reviews. Patients rated Plaquenil 3.7/5 over Prednisone 3.2/5 in overall satisfaction.