Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Chloroquine diazepam suicide Sjogrens plaquenil rash Plaquenil for fatigue Take hydroxychloroquine with food or milk. Swallow whole. Do not chew, break, or crush. Keep taking hydroxychloroquine as you have been told by your doctor or other health care provider, even if you feel well. Do not take antacids or kaolin within 4 hours of hydroxychloroquine. What do I Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARD. It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Monitoring hydroxychloroquine Hydroxychloroquine DermNet NZ, Hydroxychloroquine Side-effects, uses, time to work What is aralenChloroquine retinopathy mechanismChloroquine lysosomal degradationChloroquine injection useSanofi plaquenil Individuals beginning HCQ therapy should be informed of the possibility, although extremely rare, of retinal toxicity, and told that periodic monitoring can lead to early recognition of some symptoms. Hydroxychloroquine is the most commonly used AM, specifically because it has a lower risk for retinal toxicity than chloroquine. Drug spotlight on hydroxychloroquine Lupus Foundation of.. Hydroxychloroquine-Induced Retinal Toxicity - American.. Hydroxychloroquine and Chloroquine Retinopathy.. Hydroxychloroquine monitoring requirements. What monitoring is required for hydroxychloroquine? No routine laboratory monitoring is required for hydroxychloroquine. For people on long-term therapy 5 years or more, an annual eye assessment ideally including optical coherence tomography should be Monitoring and Preventing Hydroxychloroquine, Plaquenil, Toxicity. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Read our disclaimer for details. Plaquenil hydroxycholoroquine is a medication used to treat lupus, rheumatoid arthritis and other inflammatory and dermatologic conditions. It is very effective and the risk of damage to the eye is very low the first five years if the patient is receiving the recommended dose and does not have special risk factors like kidney damage.