It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Hydroxychloroquine safe while breastfeeding Is plaquenil still available Our patient was receiving a combination of hydroxychloroquine and colchicine for the treatment of seronegative RA and gout. RA and gout can occur together albeit rarely, with a review in 2003 collecting only 20 cases. The reason for the lack of coexistence between these 2 diseases is still disputed. Nov 28, 2010 Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation when an infection is found, and these basically malfunction with inflammatory disorders. Mar 02, 2013 Placebo-controlled trials in RA have demonstrated significant efficacy of hydroxychloroquine, both as a monotherapy and in combination with other RA drugs, and - due to its excellent safety profile it remains a popular therapy for RA. Although hydroxychloroquine’s mechanism of action in RA is poorly understood. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Plaquenil for seronegative arthritis Hydroxychloroquine Plaquenil, Inflammatory Osteoarthritis And Plaquenil Plaquenil prototypePlaquenil and diahreah Yes I have seronegative rheumatoid arthritis and it's not fun. It's harder to find meds bc most of these meds that go thru clinical trials r for ra patients with a positive rheumatoid factor. I've been on pretty much every med with no success. There is only a small percentage of ra patients whom r seronegative. Seronegative rheumatoid arthritis - Cure Arthritis Co.. Hydroxychloroquine effectiveness in reducing symptoms of hand.. Steps to Recover from Rheumatoid Arthritis - Amy Myers MD. According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with arthritis. It can also reduce the incidence of joint damage, thus lessening the risk of developing a long-term disability from complications of RA. In the vast majority of people with Rheumatoid Arthritis RA whether seronegative or proven with lab results mainly a positive anti-CCP, RA started either in the hands or feet. That's usually where the party starts but, with RA, there are many places it moves to. Welcome to the board! Regards, TheWino Plaquenil hydroxychloroquine "Hi, I was taking the generic form of plaquenil for over 10 years for rheumatoid arthritis. It took a few weeks to see it work but what a change for the better. It took a few weeks to see it work but what a change for the better.