Additionally, another exception occurred while executing the custom error page for the first exception. Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Skin cancer side effect of plaquenil Chloroquine food cravings Hydroxychloroquine Maculopathy An Update on Screening and Diagnosis A brief guide for imaging SHIRI SHULMAN, MD. H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. None of the patients who took hydroxychloroquine and tamoxifen concurrently showed crystalline deposits or macular edema that is characteristic of tamoxifen retinopathy, 17 but they all had parafoveal outer retinal damage and were classified as having hydroxychloroquine retinopathy. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Hydroxychloroquine retinal deposits Ocular Disease Monitoring Critical to Avoid Retinal Toxicity from., Toxic Retinopathy With Hydroxychloroquine Therapy - The JAMA Network Can plaquenil cause vertigoPlaquenil chronic fatigue syndromeChloroquine pubchemWhat is hydroxychloroquine generic forBrand name plaquenil better than generic Hydroxychloroquine rarely can be seen as deposits in the basal epithelium of the cornea as shown in this image white arrows. This occurs commonly in patients taking chloroquine, but rarely in patients taking hydroxychloroquine. There is no relationship of this finding to the presence of hydroxychloroquine retinopathy. Hydroxychloroquine Keratopathy - Example #1 - The Retina Reference. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Retinal thinning was also significantly greater in group II compared with group III and IV eyes at 1 mm. However, there was no difference in retinal thickness at 0.5 mm. Measurement of retinal thickness at 1.0 mm from the foveal center may therefore assist in early detection of retinal damage in patients taking chloroquine or hydroxychloroquine. Sometimes Plaquenil can also deposit in the tissues of the body and cause the skin to take on a greenish tone. Dry skin Loss of appetite Abdominal bloating Upset stomach Stomach cramps Retinal damage There is a small chance that retinal damage will occur while taking hydroxychloroquine Plaquenil or chloroquine Aralen. Chloroquine and hydroxychloroquine bind to melanin in the retinal pigment epithelium RPE and cause damage to the macular cones outside of the fovea. The drugs inhibit RPE lysosome activity, reduce phagocytosis of shed photoreceptor outer segments causing an accumulation of outer receptor segments.