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According to the WHO, over the ten years from 2000 to 2010, the number of patients with diabetes in the world increased by 46% and amounted to 221 million people, which significantly exceeded the 2000 forecast. Biguanides are used in medical practice for over 50 years. Leading medical organizations today recommend starting treatment for type 2 diabetes with a combination of lifestyle changes and the appointment of metformin. In this regard, of particular interest are the new results concerning the newly discovered properties of metformin. Metformin was introduced into clinical practice for the treatment of type 2 diabetes in 1957 in Europe and in 1995 in the USA. The mechanism of the antihyperglycemic effect of metformin has been well studied. Currently, metformin is the most commonly prescribed oral hypoglycemic agent in Europe, the USA and other countries (R. 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