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Xenical is the prescription dose (120 mg) of orlistat. Xenical is approved by the Food and Drug Administration and intended to be used by individuals with a body mass index (BMI) of 30 or more or a BMI of 27 along with a weight-related condition like type 2 diabetes or hypertension. Xenical can also be used for people who have lost weight and want to prevent weight regain. Xenical is designed to be used along with a low-fat, low-calorie diet. Those who lose weight with the medication are more likely to be successful over the long-term and keep the weight off for good if they follow a healthy lifestyle. This type of medication is called a lipase inhibitor because it helps your body to absorb less fat from the food that you eat. 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